Retinoids 101: Types, Potency, and Cheat Sheet

The world of retinoids is not as simple as it seems! While the term "retinol" is often used broadly, there is actually a variety of retinoids with different properties. Let us break it down for you:

Retinoids are a group of derivatives of vitamin A that work wonders for the skin.

1. Increasing Cell Turnover: Promoting the shedding of old skin cells and the generation of new ones.
2. Improving Skin Tone and Texture: Smoothing the skin and evening out pigmentation.

3. Stimulating Collagen Production: Helping to reduce wrinkles and fine lines by boosting skin elasticity.

Among the retinoids, retinoic acid, also known as tretinoin, stands out as the only pure form directly utilized by the skin.However, it is available only with a prescription. On the otherhand, retinyl palmitate, retinol, and retinaldehyd (retinal) arecommonly found in over-the-counter products. Additionally,there are newer forms like HPR (HydroxypinacoloneRetinoate) and plant-based alternatives like bakuchiol.


What are the different TYPES OF RETINOIDS?

Retinoic Acid (Tretinoin):
Retinoic acid, or tretinoin, is the purest form of vitamin A, directly used by the skin. It’s highly effective for severe acne, wrinkles, and sun damage but is prescription-only due to its potency.

Retinyl Palmitate:
Retinyl Palmitate is a retinol ester that is stable and less irritating, ideal for beginners and sensitive skin. It converts to retinol, then retinaldehyde, and finally to retinoic acid.

Retinol:
Retinol is a common retinoid that converts to retinaldehyde and then to retinoic acid. It’s effective for anti-aging and acne, less potent but more tolerable than retinoic acid.

Retinaldehyde:
Retinaldehyde converts directly to retinoic acid, making it faster and more potent than retinol. It offers significant anti-aging benefits and is well-tolerated.

Hydroxypinacolone Retinoate (HPR:
)HPR is a direct-acting retinoid ester of retinoic acid that doesn’t require conversion. It provides high efficacy with less irritation, suitable for various skin types.

Bakuchiol:
Bakuchiol is a plant-based alternative to retinol, offering similar anti-aging benefits without irritation. It’s ideal for sensitive skin.


What are the different TYPES OF RETINOIDS?

Retinoic Acid (Tretinoin):
Retinoic acid, or tretinoin, is the purest form of vitamin A, directly used by the skin. It’s highly effective for severe acne, wrinkles, and sun damage but is prescription-only due to its potency.

Retinyl Palmitate:
Retinyl Palmitate is a retinol ester that is stable and less irritating, ideal for beginners and sensitive skin. It converts to retinol, then retinaldehyde, and finally to retinoic acid.

Retinol:
Retinol is a common retinoid that converts to retinaldehyde and then to retinoic acid. It’s effective for anti-aging and acne, less potent but more tolerable than retinoic acid.

Retinaldehyde:
Retinaldehyde converts directly to retinoic acid, making it faster and more potent than retinol. It offers significant anti-aging benefits and is well-tolerated.

Hydroxypinacolone Retinoate (HPR:
)HPR is a direct-acting retinoid ester of retinoic acid that doesn’t require conversion. It provides high efficacy with less irritation, suitable for various skin types.

Bakuchiol:
Bakuchiol is a plant-based alternative to retinol, offering similar anti-aging benefits without irritation. It’s ideal for sensitive skin.

CONVERSION PROCESS AND POTENCY of Retinoids

Retinoids need to be converted into Retinoic Acid (the active form) to be effectively used by the skin. The longer the conversion process, the lesser the potency and irritation.

Retinoids conversion process infographic Depology skincare


Retinoids Cheat sheet for all skin types

 

Depology skincare model retinoids results

 

Retinoids Converstion Steps Potency Uses Irritation Risk Notes

Retinyl Palmitate
/Retinol Ester

3 Steps

Low

Anti-aging,
Beginners,
Sensitive Skin

Low

Most stable and least
irritating form,
ideal for beginners
& sensitive skin

Retinol

2 Steps

Medium

Anti-aging, Fine
Lines, Wrinkles,
Acne

Medium

Widely used &
effective, less
irritating than retinaldehyde
and retinoic acid but
more potent retinyl palmitate.

Retinaldehyde
/ Retinal

1 Step

High

Anti-aging, Fine
Lines, Wrinkles,
Acne

Medium to
High

Acts faster than
retinol duel to fewer
conversion steps,
potent with significant
anti-aging benefits,
moderate irritation potential

Retinoic Acid
(Tretinoin)

None
(already active)

Very
High

Severe Acne,
Deep Wrinkles,
Sun Damage

High

Direct used by the
skin without conversion,
most effective but also
the most irritating,
available only by
prescription.

Hydroxypinacolone
Retinoate
(HPR)

None (direct- acting)

High

Anti-aging, Fine
Lines, Wrinkles,
Acne

Low to
Medium

Binds directly to
retinoids receptors,
high efficacy with less
irritation, suitable for
a broad range of
skin types

Bakuchiol

Not a retinoid,
mimics retinol

Low to
Medium

Anti-aging, Fine
Lines, Wrinkles,
Acne, Firmness ,
Hyperpigmentation

Very Low

Plant-based
alternative to retinol,
offer similar benefits
without irritation, ideal
for sensitive skin.

 


dermatologist REcommended REtinoids Depology:

01. Retilogy™ Retinal 0.05% Renewing Serum

This retinoid serum, with its 0.05% retinal concentration, is a gentle yet potent choice for improving the look of skin. It is best suited for novice or intermediate users.

Sold out



02. Retilogy™ Retinal 0.1% Renewing Serum

This 0.1% retinal concentration serum is designed for mature skin types and people who have used retinoid treatments before. It provides a sophisticated method of addressing apparent indications of ageing and is intended to help improve complexion overall.

Sold out


conclusion: understanding the use of retinoids

Understanding the retinoids conversion process is key to maximizing their benefits for your skin. By recognizing how different forms of retinoids are transformed within the skin, you can make more informed choices about the products you use and set realistic expectations for their results. Whether you're using over-the-counter retinol or a prescription-strength retinoid, knowing how these powerful ingredients work will empower you to optimize your skincare routine. Remember, patience is crucial with retinoids, as their conversion process takes time. With consistent use and the right product, you'll be on your way to healthier, more radiant skin.