Nobody does Matrixyl® 3000 like we do.
We've spent years researching ingredients and products, and we've finally produced and curated the ideal collagen serum for your skin's needs. We've made it our mission to make sure you have the best skin possible at all times.
We've put together a complete guide on how to use Depology's Matrixyl® 3000 Collagen Serum in your skincare routine, including all of the dos and don'ts you may be unaware of. But first, consider why you need this incredible and effective solution in your skincare routine to treat your skin concerns.
The unholy trifecta of skin problems is dynamic lines, lack of firmness, and pigmentation.
Thank heavens, Depology Skincare Matrixyl® 3000 contains four important elements that take your skin's appearance to the next level and may be the serum you've been looking for to solve your troubles. A powerful peptide complex minimize fine lines and wrinkles, while hyaluronic acid nourishes and plumpifies skin. This versatile serum is a must-have in your anti-aging arsenal.
How To Use Matrixyl® 3000 Serum : Complete Guide
how to use matrixyl® 3000 serum in your routine
- Cleanse and tone the skin thoroughly.
- Simply add a few drops of serum to your palm and gently massage it over your face, neck, and hands, or any other places where wrinkles are more prominent.
Apply liberally to areas prone to wrinkles as we age, such as the forehead and around the eyes. Our water-based serums combine well with various anti-aging serums especially our Argireline™ peptide complex serum to improve the overall skin.
- Additional choice apply your favourite Micro-Dart patches once the serum has completely absorbed into the skin. When the Micro-Darts come into touch with the skin, they begin to dissolve and activate the serum.
- Finishing with applying moisturiser to your face so it can effectively lock in key ingredients.
Apply the moisturiser around the patches if you are wearing them.
Click The Image Above To Bring You Directly To The Video ☝🏼(old bottle design)
Natasha B (The Beauty Junky Monkey @beautyjunkymonkey has become a popular familiar face in the skincare world when her TikTok serums suggestions that went viral.
The tiktok skincare influencer/creator/beauty guru is also a professional skincare consultant and licensed esthetician who has showcased products that have assisted women of all ages in slowing down the ageing process. She recently left her 15-year employment as an police officer serving her community to become a beauty consultant, designing and creating skincare routines tailored to women's skin goals.
best matrixyl® 3000 pairing ingredients :
Argireline = ✅ Matrixyl
Argireline is a peptide that helps relax facial muscles, reducing the appearance of dynamic wrinkles like crow's feet and forehead lines. When combined with Matrixyl, which supports the skin’s natural repair processes and enhances skin firmness, the duo delivers a powerful anti-aging effect. Together, they can smooth out both static and dynamic wrinkles, making the skin appear firmer, younger, and more rejuvenated.
How to layer Argireline with Matrixyl:
- Argireline first – Apply Argireline to clean skin, focusing on areas prone to dynamic wrinkles like around the eyes and forehead. Allow it to absorb fully.
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Matrixyl second – Follow with Matrixyl to enhance skin firmness and target both static and dynamic wrinkles, making the skin appear more youthful.
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Hylauronic Acid = ✅ Matrixyl
Our major ingredient, Hylauronic Acid, aids in the binding of water to collagen, retaining it in the skin for a plumper, more hydrated appearance. Our supercharged serum is designed to moisturise the skin while also combating visible signs of ageing and reducing the appearance of fine lines and wrinkles.
How to layer Hyaluronic acid with Matrixyl:
- Hyaluronic Acid first – Apply Hyaluronic Acid on freshly cleansed, slightly damp skin. It helps draw moisture into the skin, enhancing hydration.
- Matrixyl second – Once the Hyaluronic Acid has absorbed, follow up with your Matrixyl serum to support skin firmness and target fine lines and wrinkles.
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Niacinamide = ✅ Matrixyl
Yes, mixing niacinamide and peptides is perfectly safe.
When these two heavyweights are combined, the skin's lipid barrier retains the right quantities of water and oil, strengthening it and allowing it to protect the skin's surface from hazardous free radical damage.
How to layer Niacinamide with Matrixyl:
- Niacinamide first – After cleansing, apply Niacinamide to regulate oil production and strengthen the skin barrier.
- Matrixyl second – After the Niacinamide has absorbed, layer Matrixyl to target signs of aging and improve skin elasticity.
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Retinol + Tretinoin = ✅ Matrixyl
Unlike retinol, matrixyl is less likely to cause irritation and undesirable skin side effects such as an increased risk of UV damage. If you've been using retinol or retinoid creams for a long, there's no reason to get rid of them. Matrixyl and retinols work really well together.
Look for a Matriyxl 3000 product that addresses additional skin concerns in addition to retinol.
How to layer Retinol + Tretinoin with Matrixyl:
- Retinol or Tretinoin first – Apply your retinol or tretinoin in the evening on clean, dry skin. Allow it to fully absorb to avoid irritation.
- Matrixyl second – Once the retinoid has absorbed, apply Matrixyl to soothe the skin and enhance its anti-aging benefits. Retinoids can sometimes be drying, so Matrixyl helps replenish skin’s elasticity.
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Copper Peptides = ✅ Matrixyl
Copper peptides, , act as an antioxidant, protects collagen and elastin in the skin, and soften the appearance of fine lines and wrinkles." Copper is also an anti-inflammatory that stimulates wound healing, making it ideal for the treatment of scarring, pigmentation, and redness produced by inflammation according to Natasha B.
How to layer Copper Peptides with Matrixyl:
- Matrixyl first – Apply Matrixyl to clean skin to help smooth out fine lines and promote skin firmness.
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Copper Peptides second – Follow with Copper Peptides to protect collagen, provide antioxidant benefits, and calm inflammation.
(Note: Avoid using copper peptides with Vitamin C, as they may deactivate each other.)
Can I layer hyaluronic acid with Matrixyl?
Yes, hyaluronic acid and Matrixyl are a perfect combination, offering deep hydration and collagen support when layered together.
What pairs well with Matrixyl?
Matrixyl pairs well with hyaluronic acid, niacinamide, and peptides, as these ingredients complement its anti-aging and hydrating benefits.
Should I use Argireline or Matrixyl first?
Apply Argireline before Matrixyl for targeted wrinkle relaxation, as Argireline works best as the first layer in your routine.
avoid pairing matrixyl® 3000 with :
Although matrixyl is beneficial to the skin, it does pose some hazards due to the presence of other chemicals like as vitamin C, also known as L-ascorbic acid, BHA, such as salicylic acid, and other acids, such as the popular AHA, glycolic acid. Matrixyl as well as other peptides do not combine well with acid.
- Lactic Acid (AHA) + Salicylic Acid (BHA) + Mandelic Acid = ❌ Matrixyl
If you're using a Lactic Acid or Salicylic Acid exfoliator, try not to use Matrixyl at the same time. They all have their own unique benefits, so if you use more than one at once, you may not get the best results. It's similar to Retinol, and it doesn't play well with acids. You can use Lactic Acid or Salicylic Acid on their own, but we recommend layering them with a hydrating moisturizer. That way, you'll be able to seal in their effects and make sure your skin stays moisturized. - Glycolic Acid (AHA) = ❌ Matrixyl
Other strong actives to avoid combining with Matrixyl are Glycolic acid (AHA) and Salicylic Acid (BHA), particularly glycolic acid and salicylic acid, both of which are powerful exfoliants that can cause irritation when combined with matrixyl. As a result, you should never pair them on the same night. For the most effective results, apply on different days. - Vitamin C ❌+ (AHAs) + (BHAs) = ❌ Matrixyl
Due to its fragile nature, vitamin C is a hard element on its own, and it sadly does not play well with other ingredients. Vitamin C is wonderful for brightening the skin, which is why it's found in many brightening serums, but brightening is merely code for exfoliating, which is also the primary role of AHAs. Combining the two on the same day may harm your skin barrier and create irritation, so apply them separately.
Matrixyl works similarly to retinol in terms of wrinkle reduction, but these peptides help rebuild skin and cannot do so efficiently when Vitamin C is present, so use them at night and Vitamin C in the morning. -
Mandelic Acid = ❌ Matrixyl
Mandelic acid is an acne and hyperpigmentation exfoilant. Other AHAs, such as glycolic acid, and BHAs, such as salicylic acid, should be avoided when used with mandelic acid, as should retinol and matrixyl 3000.
- Azelic Acid = ❌ Matrixyl
Due to the hydrolysis vulnerability of peptides, we do not recommend combining direct acids such as Azelic Acid with peptides like (Matrixyl 3000). This process will breaks the bonds between peptides, reducing their efficacy, and making them into individual amino acids)
Before and After using Depology MAtrixyl 3000
Powered by Matrixyl® 3000, our formula is clinically proven to improve fine lines by 5.25% and boost skin hydration by 46.31% in just 28 days. This potent peptide complex targets multiple signs of aging, delivering plumper, more youthful-looking skin.
Apply to cleansed, toned skin both morning and night for optimal results. Whether worn alone or layered with our best-selling Peptide Complex 10% Serum, this serum works to visibly reduce fine lines and wrinkles, leaving your skin firmer and more hydrated.
Discover the power of peptides and watch your skin transform with consistent use.
How often should I use Matrixyl?
Matrixyl can be used twice daily, morning and night, for optimal results. Regular use helps boost collagen and improve skin texture.
Do you put Matrixyl on damp or dry skin?
Matrixyl is best applied on dry skin. After cleansing, gently pat skin dry, then apply Matrixyl to enhance absorption and efficacy.
Can you put Matrixyl under eyes?
Yes, Matrixyl is generally safe for the under-eye area. It helps reduce fine lines and wrinkles with regular use, but avoid getting too close to the lash line.
What is the side effect of Matrixyl?
Matrixyl is typically gentle, but some users may experience mild irritation or redness. Always patch-test new products to ensure compatibility with your skin.
Can I use Matrixyl at night?
Yes, Matrixyl can be used at night to help support collagen repair and skin rejuvenation during sleep.
How long does it take for Matrixyl to work?
Results from Matrixyl, like smoother skin and reduced fine lines, typically become noticeable within 4 to 8 weeks with consistent use.
In what order do I apply Matrixyl?
Apply Matrixyl after cleansing and any water-based serums, and follow with heavier products like moisturizers and oils.
Can you use Matrixyl every day?
Yes, Matrixyl is gentle enough for daily use and can be applied morning and night to improve skin texture and hydration.
Does Matrixyl tighten skin?
Matrixyl helps to firm and plump the skin by stimulating collagen, but results may vary and are typically seen over several weeks.
is matrixyl 3000 suitable for all skin types?
The Matrixyl® 3000 Collagen Serum can be used by all genders, and on any skin type. Whether your skin is dry, oily, normal, sensitive or mature, this serum is ideal for nearly everyone looking to minimise the effects of skin ageing. It is alson Vegan, Cruelty-Free, Artificial Fragrance-Free, Sulphate-Free
Do you simply love our Matrixyl 3000® Serum and don't want to run out? Or maybe you want to gift one to a family member or a friend. This is the deal for you: Discover Matrixyl® 3000 Triple Bundle, which includes three full-size, individually packed bottles of Matrixyl 3000.
final thoughts : does matrixyl® 3000 really work?
As you can see, the multiple benefits of collagen anti-aging peptides and ever lasting results speak for themselves. However, using a collagen peptide serum is about much more than just looking good. We realise that here at Depology, it's also about giving your face some gentle loving care and treating it with the respect it deserves.
Find out the Orgin of Matrixyl - "What Does Matrixyl Do?
Click here for Benefits "What is Collagen Face Serum and the Benefits of it? "
For more answers on "Can I Use Matrixyl with Retinol? "